I am commenting on a tiny part of Anchi Baranova's stream with the title about some rain and something else.
Ancha Baranova again calls antihistamines a means of lowering body temperature. Ancha calls this temperature from a local allergic reaction peripheral temperature. And Ancha also says that there is a central temperature, which is maintained by the hypothalamus, and on which analgin acts.
It is not right. It looks like Ancha is confusing the usual increase in body temperature with the so-called central genesis fever. Brothers, I explained the mechanism of increasing body temperature in detail in several articles. Check them out at the links below.
Antihistamines do not lower body temperature, but increase it.
There is no peripheral fever. That rise in temperature, which Ancha considers peripheral, is actually realized through the same hypothalamus in our head.
That is, the sequence of events is as follows: on the periphery, in an arm or leg, something is severely inflamed and from there pyrogens enter the bloodstream. Pyrogens reach the hypothalamus and the center of thermoregulation in it. Pyrogens act on the walls of blood vessels in the hypothalamus region in such a way that they release from this wall prostaglandin E2, which causes the thermoregulatory center in the hypothalamus to change our body temperature.
It seems to the hypothalamus that we are freezing, and it raises the temperature. This is normal and is NOT called center temperature. The central temperature will be further under a separate heading.
So those antipyretics, which include analgin, they disrupt the synthesis of prostaglandin E2. If prostaglandin E2 is low, then it cannot act on the hypothalamus and does not cause it to raise the temperature.
Therefore, the temperature from analgin decreases. That is why analgin or any other antipyretic drugs cannot lower your temperature below normal. Antipyretics cut off only the action of pyrogens, but leave us a center of thermoregulation, which quietly works in a regular mode.
Central genesis temperature
And now what is actually called the temperature of central genesis. This is an increase in body temperature, which is triggered by the hypothalamus, but not due to pyrogens that floated in the blood, but due to damage to the hypothalamus.
The hypothalamus is part of our brain. And like in any part of the brain in the hypothalamus there can be a stroke, hemorrhage, or anything that damages it.
Well, imagine. If a person has a stroke in the part of the brain that is responsible for the work of the arms or legs, then the arm or leg may stop working, and they may even have cramps in the arms or legs.
The same stroke in the center of thermoregulation will disrupt its work, and the center of thermoregulation will cease to support our body temperature, or, on the contrary, will start to greatly increase our body temperature. This is what is called the central temperature.
It is clear that this is not about prostaglandins, but about damage to a part of the brain. Well, that is, if you remove the thermostat from the refrigerator, then it will not work.
Briefly speaking
If a person really has a central increase in body temperature, then antipyretics will most likely not work on him. Got it?
Check out my articles on fever:
Why does the body temperature rise?
What body temperature is considered normal
Why pyrogens raise our body temperature
