Scientists have taken an important step in understanding the features of this hormone
How does the satiety hormone leptin work?
Leptin is a hormone responsible for satiety in our body.. It is produced when we have eaten and inhibits hunger.
But the paradox is that people (and mice) with obesity in the blood, the level of leptin is always high, but the sensitivity to it disappears. It ceases to affect appetite and the consumption of accumulated fat. Moreover, as soon as a person loses weight and the level of the hormone drops,the real hell is coming.
What is the essence of scientific discovery
Scientists have found a way to restore the normal action of leptin. Fat mice, which were injected with special inhibitors, again began to respond to this hormone and lost weight. On average, 25 percent of the original weight.
Moreover, it was the hated fat that was dumped, and not the muscles. Skinny mice stayed skinny.
Moreover, other indicators also returned to normal - for example, glucose tolerance increased, respectively, the risk of diabetes decreased.
The results of the study are published in the journal nature metabolism.
What will this discovery bring in the future?
But it is still impossible to give these magical substances to people: in the process of decay, they become potentially toxic. But most importantly, we now know where to look.
More importantly, the substance that increased leptin sensitivity also affects adipokine, a hormone in adipose tissue. And this is now the most coveted target among scientists who deal with obesity. Everyone is looking for ways to influence him. If they learn to manipulate adipokines, sensitivity to it, then the fight against obesity will become very successful and effective.
Your Doctor Pavlova
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