There is such a thing. Metformin is a medication used to treat type 2 diabetes. It is clear that if a person receives metformin, then his blood sugar may be increased.
Indapamide is a kind of diuretic, which occasionally can provoke the development of type 2 diabetes mellitus.
The fact is that indapamide, like many diuretics, expels potassium along with water. Potassium in the blood can become less, and, accordingly, potassium will flow from our cells to our blood in order to compensate for these losses.
It should be noted here (you yourself wanted to hear it) that normally our potassium is just hidden inside the cells. The potassium ion is positively charged and its task is to maintain a certain number of such plus-charges inside our cells.
Outside the cell membrane, the plus sign is controlled by a positively charged sodium ion, and inside the cell, potassium is responsible for the plus sign.
Different ions constantly flow and flow from the cell and into the cell, but in order for the cell to start, crackle with electricity, work like motor, began to spark, live, rejoice and secrete all sorts of hormones like insulin, she must accumulate the right amount inside herself plus signs.
And here potassium sits inside the cells of the pancreas and protects its pluses. At the right time, many positively charged sodium ions will enter these cells, and there will be a lot of advantages. The pancreatic cell will work and begin to secrete insulin. This insulin prevents blood glucose from jumping too much. This is normal.
But if there is little potassium in the blood, then the potassium from the cells of the pancreas will go into the blood. That is, there will be fewer plus signs inside the cells. It turns out that at the right moment sodium drives its pluses inside the cells of the pancreas, and at this time potassium, on the contrary, drains its pluses out.
It looks like if you pump a punctured wheel in a car with a pump: we pump it in there, and it bleeds out even faster through the hole.
And the cells of the pancreas cannot accumulate enough pluses inside themselves to throw out insulin. Potassium constantly leaks out of cells and prevents cells from working.
This is one harmful mechanism.
Lactic acidosis
This is when there is so much lactic acid in the blood that a person becomes ill.
Diuretics, including indapamide, act on the kidneys in such a way that they predispose to the development of lactic acidosis.
Metformin is by nature geared towards stopping lactic acid from converting to glucose. That is, its main task is to prevent an increase in blood glucose levels. He does this in different ways, including due to the fact that it prevents our native lactic acid from being converted into glucose. And then there is indapamide adds fuel to the fire and provokes the accumulation of lactic acid in the blood. So together they can do trouble.
I am not saying that this is a downright hellish combination, but it requires supervision and caution on the part of your doctor.
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