In fact, these enzymes destroy our own DNA.
In another stream about the brain, the outgoing summer and something else there, Anchu Baranova, someone asked about inhalations of hyaluronidase for the prevention of pulmonary fibrosis after pneumonia. Ancha instantly came up with some interesting ideas that have nothing to do with reality. In a few sentences, she has such a big story that I will have to publish now a separate article on this topic.
So. Ancha expressed doubts about enzyme inhalation. She said that for example there is the Dornaz enzyme. It destroys the DNA of bacteria that infect the lungs. And now she really works. I, he says, understand the mechanism of this Dornaza.
And hyaluronidase, according to Anchi, will make a hole in the lungs, because it breaks down the collagen that has formed at the site of the lung tissue.
Now I am explaining. Dornase is really an enzyme that breaks down DNA. But Ancha still does not understand the mechanism of its action. Because Dornaza does not destroy the DNA of bacteria, but our own DNA.
Dornaza destroys DNA. We also have this enzyme in our blood. Sometimes, for example in people with cystic fibrosis, a lot of thick sputum is formed in the lungs, on which many pyogenic microbes settle. Our leukocytes fight against microbes, and as a result, a lot of pus is obtained.
So after our own leukocytes die in an unequal struggle with microbes, they do not just fall apart, but release their DNA outside. It literally unwinds in the form of a net, and microbes become entangled in it. This process is called netosis. We are with you already discussed.
This web of DNA strands entangles the flagella well for microbes and helps to kill them. But it's still a network. It makes the phlegm even more viscous. Therefore, people with cystic fibrosis are inhaled an enzyme that breaks down these networks of DNA.
This is our own DNA, but it must be dissolved so that it does not interfere with the secretion of phlegm. This is not bacterial DNA.
Let's go further. Hyaluronidase dissolves the connective tissue base. At all times, they tried to adapt hyaluronidase for resorption of scars, but there was no great benefit from it. And just recently, it was proposed to use hyaluronidase for acute respiratory distress syndrome. We are with you also discussed.
There, with this acute respiratory distress syndrome, membranes are formed in the alveoli of the lungs, which interfere with gas exchange. Theoretically, hyaluronidase can dilute these membranes. But this, in my opinion, is still in theory. I have not heard anything about this case.
Briefly speaking
It turns out a conversation between two people who are both off topic. And these are just comments on one question. And there are a hundred of these questions. Are we going to continue?
