The doctor examines the most popular means - "restorers" of the liver. Part 2
There are a lot of hepatoprotective drugs. And the main problem with them is weak, if not absent, evidence base. In the first part, I talked about the only drug whose effectiveness is not suspicious.The only "But": this is a powerful medicine with its own contraindications.
Therefore, I continue to talk about other drugs that deserve attention.
Adenosylmethionine (S-Adenosyl L-Methionine) (SAM)
+ Antioxidant;
+ Promotes the synthesis of structural proteins of liver cells;
+ Provides a reaction of bile acids (sulfuration), making them non-toxic.
+ Prevents stagnation of bile (anti-cholestatic effect)
It is an essential substance that is involved in many biochemical reactions, the violation of which can lead to a lack of an essential detoxifier (toxin neutralizer) - glutathione. And without him liver cells simply die.
In addition, SAM serves as the basis for the production of thiol compounds (sulfur-containing substances) that contribute to the restoration of liver tissue.
Under the influence of adenosylmethionine, the liver tissue regenerates faster, as demonstrated by many scientific works. It also inhibits the formation of fibrosis - the replacement of useful liver tissue with completely useless connective tissue.
In 1999, data from a serious research patients with alcoholic cirrhosis of the liver.
It turned out that people with liver cirrhosis class A and B (if very rough, the initial and middle stages of the disease), improved liver performance. The survival rate also increased.
But if you study the total sample, including class C patients (last stage), no difference with placebo was found.
That is to say the boundaries of liver damagein which this drug stops helping.
There is an interesting information on the use of ademetionine in pregnant women with intrahepatic cholestasis (ICB). By itself, he was strongly inferior to ursodeoxycholic acid in this pathology, but their combined intake improved the performance.
The end follows ...
Your Doctor Pavlova
Part 1 How to restore the liver: the only effective remedy
