Brazil is not just an epidemic. There is now hell. Even tighter than in India. There are slightly fewer cases of the disease, and almost 2 times more deaths. But the Brazilians have abandoned our Satellite.
As the Brazilians explain it
They believe that Sputnik contains an adenovirus that can multiply in our body. And this is not acceptable for a vaccine.
Does that even happen?
Of course it happens. This is a known problem with adenoviral vectors grown in HEK293 cell culture.
That is, for the vaccine, manufacturers make an adenoviral vector that cannot multiply in human cells, because this place was cut out for it.
But a vaccine needs a lot of vector. So how do you propagate it? It is propagated in HEK293 cell culture. It is a hybrid of a human cell and adenovirus.
Such a cell has everything a vector needs to reproduce. That is, the cell complements it. It turns out that the adenoviral vector can propagate only in the culture of these hybrid cells.
But Nature is cunning, and the adenovirus vector sometimes manages to scratch out the necessary genes from hybrid cells. If he then enters the human body with these genes, he will be able to reproduce in it.
Manufacturers of vector vaccines write on their vaccines that they tested this batch of vaccines and did not find anything multiplying there.
But this could theoretically be. That is, a freak can always appear who yells that it is in this particular batch of vaccine that he found something multiplying.
What's bad about it
If the vaccine vector multiplies, it can cause something like an infection. Most likely this can be in people with weakened immunity.
In general, in the case of the adenoviral vector from the Sputnik vaccine, it is somehow difficult to imagine serious harm from such a reproduction.
First, the adenovirus itself is imprisoned for reproduction in our nose. In snot. He does not know how to multiply in the muscle where the vaccine is injected. Yes, and our immunity will quickly squeeze him.
Secondly, even if the vaccine wants to multiply in our shoulder, there will be no more of it than in the studies that the manufacturer conducted. And the manufacturer of the vaccine has already injected it into various laboratory animals in frantic doses. The animals endured.
In short, for some reason I doubt that there will be a lot of harm from the multiplication of a certain amount of the adenoviral vector.
It seems to me that someone is putting pressure on the Brazilians, and they are inventing all sorts of nonsense about our Sputnik.
