In yesterday's comments the British, about our Sputnik, a remark flashed that the adenovirus vector from such vaccines can launch not only the gene of a dangerous virus important for immunity, but also its adenoviral genes can also unfold. Well, they gave a link to the British study on this topic.
The point was this. British scientists took their vector vaccine based on chimpanzee adenovirus and injected it into human cell cultures.
Such cultures of human cells are stored in special banks. I mean, not in glass jars, but in storage facilities.
Some of the cells that the British used in the experiment were normal, and some were tumor. It is convenient to work with tumor cells because they are immortal. Just add veal serum and antibiotics to them so that they don't go bad, and the cells will multiply endlessly.
And now it turned out that in normal human cells, the monkey vector behaves decently, and in tumor cells it starts to launch some of its hidden adenoviral genes.
Well, that is, the chimpanzee adenovirus successfully coped with the delivery of the desired gene into the cell nuclei, but at the same time it still had time to start the synthesis of some of its adenoviral proteins. There were very few of these proteins, but scientists caught them using special methods.
It's hard to say what that means. And the tumor cells themselves, on which such an outrage occurred, were not normal. In those cells, even the chromosomes were one and a half times the norm.
In short, the fact took place. The English anticonoid vaccine based on the monkey adenovirus vector managed to slip into some cells not only a useful gene, but also its own genes. At least it wasn't our vaccine. And thanks for that!
