This drug has a unique approach to killing bacteria. Previously, nothing like this was observed by scientists, writes medikforum.
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Researchers from Canada believe that the corbomycin they discovered could be a candidate for components of a new generation of antibiotics. New drugs in this class are required due to the growing threat of antibiotic resistance. Every year, 700 thousand people become its victims, but WHO believes that soon the bill will go to the millions.
Corbomycin, along with the lesser known antibiotic complestatin, kill bacteria by blocking the functionality of cells in their walls. This phenomenon is observed by science for the first time.
"Bacteria have a wall around the surface of their cells that provides their shape and is a source of strength," - says Beth Culp, PhD in Biochemical and Biomedical Sciences at McMaster University in Canada Culp). “Antibiotics like penicillin kill bacteria by blocking the building of this wall, but the drugs we found do the opposite. They prevent the walls from collapsing. And if this process is blocked, then the cells are locked up, they cannot expand and grow, which dooms them to death. "
Tests in mice have shown that antibiotics block Staphylococcus aureus infections, i.e. a group of drug-resistant bacteria that cause serious infections such as sepsis and syndrome toxic shock. Both antibiotics belong to the group of glycopeptides produced by soil bacteria.
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