In the edition of New Scientist recently passed the message of the third in the history of the world the person cured of HIV. This patient, like the other two previously been transplanted bone marrow from a mutation in the CCR gene. We recall that it was this mutation is capable of providing medium resistance to infection with the HIV virus.
According to statistics for 2017, the carriers of the human immunodeficiency virus in the world was 37 million patients. More than half of these people regularly taking special medications and could lead quite a normal life.
However, drugs such people have to be taken regularly over a lifetime. Although not everyone infected has at their disposal. So the method of suppressing the viral action of pharmaceuticals and easier life would be extended to many more patients.
However, progress in this direction, as they say, "on the face." Not long ago a sensation was the only victory over HIV - medical history of the American Timothy Brown (the very "Berlin Patient"). In 1995 he was diagnosed with HIV, and in 2007 had a transplant of bone marrow stem cells with a mutation of the CCR5 32.
This gene "encodes" in its own one of the receptor proteins, which bind to HIV virus particle. Deletion of the 32 nucleotides in the CCR5 gene leads to inability to bind to receptors virions. As a result, a carrier of the mutation gets immunity to HIV infection.
Most recently, in the publication Nature published an article, explains: "The Brown case" - is no exception! Described another case in which the HIV-infected Londoner, lymphoma patient, perform a bone marrow transplant - just from a donor with the mutation in 32 CCR gene. And today we can talk about it in remission and a half years long. When the patient stopped taking antiretroviral drugs prescribed to him more than a year ago.
Recovered a third of HIV patients come from the German Düsseldorf. He also underwent bone marrow transplant from a donor with the mutation. And now 3 months as people stop taking the drug, and in his analysis does not find viable virions. According to the scientists from the University of Utrecht, is currently under observation for a few more HIV-positive people who desired a bone marrow transplant was performed.
In 2018 scientists at the Russian human embryos were obtained (total 250 cells) 32 which carry a mutation in the gene CCR5. And before that, our physicians have been conducted clinical trials (until basic) completely new experimental vaccine against HIV, proving its safety.
Want to know more about medicine? Do not forget to support our channel in service Yandex. Zen Like and subscription. It motivates us to publish more interesting materials. Also, you can quickly learn about new publications.
