Nonsteroidal anti-inflammatory drugs (NSAID) used to relieve pain and reduce inflammation. This is the most popular medications. Such funds are often sold without a prescription. They are produced in many forms, including gels and ointments. Due to the fact that the use of NSAIDs at every step, they often cause side effects.
How to choose NSAIDs?
It is very difficult to predict how the drug will affect the individual. It happens that has to be prescribed the drug and monitor the effect, and then assign the other to compare.
local NSAIDs
NSAIDs are often produced in the form of ointments and gels. In joint diseases or for back pain which may be quite suitable for this. Medications will act, and less chance of side effects.
How are NSAIDs?
NSAIDs inhibit the enzyme called cyclooxygenase (COX). This reduces the number of substances that support inflammation and pain. Together the harmful properties and useful COX suppressed. This is the cause of side effects.
types of NSAIDs
NSAIDs are divided into two broad classes: selective and unselective. They differ in how inhibit COX.
Non-selective NSAIDs inhibit both types of COX (COX-1 and COX-2).
Selective advantageously inhibit COX-2. This is a very important feature, because COX-1 is necessary for the stomach to work properly platelets and blood vessels.
nonselective NSAIDs
Nonselective NSAIDs are usually sold without a prescription. It is remarkable: ibuprofen, aspirin, naproxen, and others. Nonselective NSAIDs is not desirable to accept people with coronary heart disease or a stroke, or at high risk of these diseases.
selective NSAIDs
They are called selective inhibitors of COX-2. This, for example, tseleksoksib and etoricoxib. Sometimes they are called coxibs. Such drugs are less irritating to the stomach, so they are prescribed to patients with peptic ulcer disease and similar problems.
With heart disease, these drugs can be even more dangerous than non-selective NSAIDs. Therefore, they are sold by prescription.
