Zuhra Pavlova, an endocrinologist and scientific MSU University Hospital. hands. "Hospitals system of medicine" by channel t.me/doctorpavlova
In recent years, against the backdrop of the collapse of unbridled medicine, vast amounts of information and the feeling that the rescue of drowning, the handiwork of drowning has led to so many unreasonable appointments, including testosteronzamestitelnoy therapy, where it is absolutely is shown.
I love this hormone, and have extensive experience of hormone replacement therapy (HRT), gormonvosstanovitelnoy therapies. And I think it's a dizzying benefit today, have in the arsenal of medications and knowledge regarding HRT. However, HRT has its indications and contraindications. If it comes down to, to be able to look at the test results, see the bold and the data Googling the dose of a drug, then this would not be necessary in the long-term training and follow-up medical institutions the specializations.
Where the body is arranged wiser than it might seem. And each person has a genetically defined, the threshold for each hormone. In other words, testosterone is not the end product of steroidogenesis. From it will still estradiol and dihydrotestosterone. And when someone thinks that 15 or 18 nmol / L is the concentration of small and would be good to see the figure of 35 nmol / L, it mindlessly, I would say, foolish and dangerous.
Many, tending to these figures, large doses of testosterone administered solutions are used and the gel simultaneously hCG (Human chorionic gonadotropin), and gel injection, and much more staggering schemes realize that impossible. Unequivocally clear that assigns these schemes, it is superficially familiar with the pharmacokinetics and pharmacodynamics and more drawn to Dr. Evil than Dr., in the conventional sense, yet.
Supraphysiological doses of testosterone by the body perceived akin to poisoning and the body tries to get rid of what suddenly became a lot. Down regulation (excess amount acting on the hormone receptors, leading to their simultaneous immersion most available receptor in the cell, leading to increase of the activity of two enzymes, followed by reduction with 5 cell surface receptors) Alpha reducers.
You will rise to dihydrotestosterone and may accordingly safely expect baldness, acne, benign prostatic hyperplasia and adenoma her.
.A second active enzyme aromatase, and increase estrogen synthesis, and this will give you the growth of breast cancer (False or true gynecomastia), increased cardiovascular risk, increase the volume of adipose tissue and risk Oncology. TZT should be, but where it is necessary to replace the reduced or lost function. And it really is priceless, but in reasonable hands.
Testosterone is also necessary to replace when it is not enough, as the substitute for the lost or reduced thyroid function.
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