Zuhra Pavlova, WHC, endocrinologist MSU University Hospital, scientific director of the Clinic for Systems Medicine, https://t.me/doctorpavlova
Another stream of questions highlighted another vital topic that today and we will cover. Question - what and how useful the plant Aloe Vera?
Aloe - representative of the family xanthorrhoeaceae, which is considered the birthplace of North-East Africa, possibly Sudan. Then, the plant appeared in other parts of Africa, India, Asia, America and Europe. Excellent, this plant grows in the home, in the flats, but rarely bloom at the same time. Incidentally, the flowers do not have therapeutic properties. They are a huge number, about 500 species. The bulk of them native to the arid regions of the tropics, which is why they are able to retain water. For therapeutic purposes, use less than 20 species of the genus Aloe, two of which have proven themselves as much as possible effective is Aloe Vera (Aloe Barbadensis Miller, also known as Aloe Vera or aloe vera), and tree-like aloe or agave. Medicinal properties of both types are similar, but have some otlichiya- aloe arborescens is more effective when skin diseases, and is used under external influence, while aloe vera works perfectly in the internal environment body.
4-piece aloe leaf (rind, juice, gel-like pulp and mucilage), it peels associated with side effects, so it is not worth using.
We will talk more about Aloe Vera. 97% consists of water. The remaining 3% contain more than 250 biologically active substances, which makes it unique. This and esters and essential oils, and volatile, flavonoids, tannins and resins, and simple organic acids (succinic, malic, citric, etc.) and amino acids (about 20), including the essential, that is, those that can not be synthesized in our body or synthesized amount can not compensate needs. Mikronutrientov- large number of vitamin B, E, A, beta-carotene, C, calcium, manganese, potassium, copper, selenium, phosphorus, chromium, magnesium, sodium, zinc, mono- and polysaccharides (glucomannans and acemannan) alonin emodin and (provide analgesic, antibacterial, antiviral and antifungal properties, and a beneficial effect on carbohydrate metabolism, increasing insulin sensitivity, and contribute to the normalization of the lipid profile, effective laxative) and even gormonpodobnye substance -auksiny gibberellins and possessing anti-inflammatory properties and high regenerative properties.
Briefly talk about which can be applied aloe vera, it is almost all branches of medicine- cardiology (endothelial dysfunction, systemic inflammation), dermatology (autoimmune and many other skin diseases), gastroenterology (Mucosal inflammatory disease of the gastrointestinal tract), Endocrinology (disturbance of carbohydrate and fat metabolism) Immunology (Viral diseases), ophthalmology (inflammatory zabolevaniya- uveitis, conjunctivitis, keratitis), dentistry (gingivitis, stomatitis), and a lot others. Let us turn to serious medical sources and describe what the most important and more credible.
Most discussed effect of aloe vera is its anti-tumor effect. On this subject, there are a number of articles that are useful to read and to know what these properties have a justification and world science It is working to ensure that anti-tumor effects of metabolites of Aloe Vera as widely used in the pharmaceutical industry.
1. Potential anti-tumor effects of Aloe-emodin: Review article.
In this review article from 2014, it was demonstrated that aloe-emodin (AE), a bioactive anthraquinone derived from aloe vera, has attracted much attention due to its antitumor activity, due to violations of the cell cycle, induction of apoptosis, and antiangiogenic effects antimetasticheskih, and generally improving the immune response.
The experimental data showed that AE is a promising molecule for the development of drugs based on it.
This review summarizes the potential toxicity, molecular mechanisms pharmacokinetic characteristics and AE pharmaceutical development as an antitumor agent. This is based on its physical and chemical properties, in an attempt to stimulate further research on AE as a potential anticancer agent.
2. Degradation of DNA with an aqueous extract of aloe vera in the presence of copper ions.
The extracts of aloe vera are a rich source of polyphenols, such as aloin and aloe emodin (AE), demonstrating the wide range of pharmacological properties, including anti-inflammatory and anti-cancer properties. It is reported that the bioactive component AE induces apoptosis in various cancer cell lines, ie, it promotes the death of cancer cells. Furthermore, AE is able to inhibit cell proliferation (i.e., number of cells cease to increase). It is reported that these abilities act via activation of the enzyme tyrosine kinase, phosphoinositol-3-kinase (PI3K), p53 or decreased activity of protein kinase C (PKC), NF-kappa B (NF-kappaB) and signal cascades mitogen-activated protein kinase (MAPK).
Many of the biological effects of Aloe Vera are related to its antioxidant properties.
However, the majority of plant polyphenols, which are also present in the aloe vera may exhibit prooxidant properties either alone or in the presence of transition metals such as copper. Previous reports included prooxidant effect as one of the mechanisms of their anti-cancer properties. In this paper it is shown that the aqueous extract of aloe vera is also capable of inducing degradation of DNA of cancer cells in the presence of copper ions. Moreover, the extract is also capable of reducing Cu (II) to Cu (I) and generate reactive oxygen species such as superoxide anion, and hydroxyl radicals dose-dependent manner, which correlates with the ability to cause destruction of the extract DNA. Thus, the study shows that in addition to the antioxidant activity of aloe vera extract also possesses prooxidant properties, resulting in damage to the DNA molecule.
3. Activation of murine macrophage cell line using acemannan: main carbohydrate fraction of aloe vera gel.
Acemannan - this is the name given to the main carbohydrate fraction obtained from the leaves of aloe vera gel. It is argued that it has several important therapeutic properties, including the acceleration of wound healing, immune stimulation, anticancer and antiviral effects. However, the biological mechanisms of these effects are not clear until the end. Because of this wide variety of effects, it is believed that they can be used through the pluripotent effector cells such as macrophages. Therefore, the effects were examined atsemanana cell line murine macrophage, RAW 264.7 cells.
It was found that acemannan can stimulate cytokine production of macrophages, release of nitric oxide, the expression of surface molecules and the morphological changes of cells.
Production of cytokines IL-6 and TNF-alpha depend on the dose of acemannan. Production of nitric oxide, morphological changes and cell surface antigen expression was increased in response to stimulation with a mixture of acemannan and IFN-gamma. These results indicate that acemannan can function, at least in part, through activation of macrophages.
From all the above can be summarized by the fact that Aloe Vera and tools based on it are expressed, the effective impact in many pathological processes, including anti-tumor effect. God preserve me to urge you to use Aloe Vera as the primary drug in the fight against cancer. I put another zadachu- show that using products based on Aloe Vera can achieve better development of many rezultata- profilaktirovat pathologies, but in combination with the correct way of life: balanced and regular meals, subject to circadian rhythms and daily physical activity. A great interest of scientists to the pantry under the name Aloe Vera, with high probability, we will provide in the near future, an effective means in the fight against the most terrible diseases.
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