Ketogenic diet - a very fashionable topic today, and unfortunately, many people get hooked on it. But if you know the biochemistry and physiology, even surface, then any desire accelerate its aging and lose health (which is exactly what is happening on the ketogenic diet) can not arise. And to whom knowledge is not enough, I'll give links to serious research.
Ketogenic diet - a reduction in the amount of carbohydrates and proteins and a significant increase in dietary fat: Saturated and unsaturated, vegetable and animal.
Ketogenic diet really gives effect, the person loses weight. But only at first. If you continue to eat within it, the weight of the first to recover, and then increase. And there will come a dangerous condition of the body, which adherents of ketogenic diet did not warn anyone.
Necessary retreat.
Ketogenic diet can be curative, if held in a hospital, under the supervision of physicians, and then the patient keeps track of blood indicators. It is necessary to maintain a special state of ketosis, (not leading to dangerous ketoacidosis) and monitor energy intake, and from time to time include interval starvation.
For example, the ketogenic diet It is indicated for drug-resistant (that is not amenable to drug treatment) of epilepsyBecause it leads to remission. Again, a caveat - when properly used, under the supervision of doctors. Does not matter They are losing health, but the lack of seizures in epilepsy is more important.
Also, it is prescribed with end-stage renal failure. The data were obtained from the short-term, single-center studies, but have a positive trend and requires further research.
There are works where the findings suggest ketogenic diet preventive effect against the background of fasting interval for Alzheimer's disease. But these are preliminary findings that require confirmation.
In most cases, I have to treat the victims of ketogenic diet, which earned obesity, often visceral enough. In fact, they were removed from their food carbohydrates and fats are added.
Fat is, you can (and should!). Just as you need to eat carbohydrates and proteins. Only moderate balanced nutrition leads to health and longevity.
What happens in the body on the background of ketogenic diet?
After each blood meal circulates a large amount of free fatty acids (Short - FFA). There are more than people who eat more rationally, respecting the balance of proteins, fats, carbohydrates.
Proteins that these FFA "catch", and function primarily synthesized in the liver. Where they are "extra" captured fatty acids? On the "base" - the liver. Thus, because of the power, the supersaturated fat, very soon we will get non-alcoholic fatty liver disease - NAFLD.
In parallel there is another very unpleasant Process - thevelicheniya in volume and in the number of adipocytes - the cells of adipose tissue.
Hundreds of thousands of years man lived in conditions of food shortages and frequent famine. As a result, energy storage occurs when food in excess. This is a key mechanism of human survival, it can not be changed (and thank goodness).
During the ketogenic diet is continued excessive intake of fat, free fatty acids becomes so much that they begin to be stored not only in adipose tissue, but also capture other organs and tissues. They form around the heart, kidneys, etc. capsules of fat, substitute a working tissue of the body.
how I have already written, constant excess (and uncontrolled) intake of fats in the body can cause a fatty degeneration of pancreatic (lipomatosis) which immediately raises diabetes risk. Firstly, because the excess fat tissue, immediately causes inflammation and oxidative stress. From this die pancreas cellsFirst of all the most important beta and alpha cells that synthesize insulin, glucagon and other hormones. They are very vulnerable to oxidative stress. Secondly, the very Useful area of the pancreas becomes less as it is replaced by fatty tissue. Accordingly, physically it decreases the production of hormones and enzymes.
Inflammation is on the rise - the more fat, the more processes, the greater the oxidative stress.
Eventually we come to insulin resistance (pre-diabetes) and a number of associated diseases, including oncology. there is link in the study, which was carried out on a culture of breast cancer cells, showing that the increase in ketone bodies (on the ketogenic diet is getting a lot of) contributed to the progression of tumor growth and active metastasize. One mechanism for increasing onkoriskov, against oxidative stress, DNA damage is the formation of point mutations and a "bookmark" of future tumors.
damage to the endothelium inflammation and the development of cardiovascular diseases, too, it is no secret. But here is the development of thyroid pathology in children with epilepsy and the ketogenic diet have been a surprise. As researchers found, hypothyroidism have developed against the background of violations of zinc metabolism, selenium, changing the balance of neuropeptides, such as gamma-aminobutyric acid (GABA), especially against the iodine deficiency. This helps reduce the synthesis of thyroxine hormone and hormone replacement therapy without developing uncompensated hypothyroidism. Also unexpectedly revealed renal disease, especially renal stone disease in children that occurred against the backdrop of ketogenic diet.
Here are the links
http://www.ncbi.nlm.nih.gov/pubmed/19400750
http://www.ncbi.nlm.nih.gov/pubmed/17621514
http://www.ncbi.nlm.nih.gov/pubmed/19596731
http://www.ncbi.nlm.nih.gov/pubmed/23951940
https://www.ncbi.nlm.nih.gov/pubmed/28076316
Similar changes and animals were. It was held an attempt to assess the effectiveness of ketogenic diet in patients with diabetes. The attempt, at first glance, quite reasonable, since the most effective treatment of diabetes is weight reduction by reducing the amount of fat tissue.
But ketogenic diet reduces muscle tissue volume, and an increase in fat, particularly in its long-term use.
Ketogenic diet led to the fact that diabetics have deteriorated performance, and underlying disease, and the cardiovascular system. Many of them have developed cardiomyopathy, ie, the pathology of the heart muscle. This can quickly lead to heart failure, which all cardiologists and patients fear. Because it is, in fact, the final stage of all the trouble, which leads, in particular, and diabetes.
Another important aspect of our health, which is broken at the ketogenic diet, it violation of the blood coagulation system by reducing the number of platelets.
There are a lot of differences. Some believe that the locked red sprout, against the background of the same ubiquitous inflammation. Others believe that the platelet membrane structure changes, due to the substitution of one form of fat - phospholipids other. In any case, the use of drugs that affect blood clotting using the ketogenic diet should be under more control.
And the data from 2019, when in a study with the addition of sweeteners and natural products containing simple carbohydrates in the background ketogenic diet, it has been revealed inhibition of mitochondrial enzymes is due to ketones. That in itself speaks about a very significant violations, not health promoting.
But why do so many people like the ketogenic diet?
First, fatty foods taste better than a low-fat.
Secondly, it eats people fasterAnd a portion, usually less. However, this calorie reduced volume, not all are thinking.
Third, the weight initially lost very quickly. But mostly, at the expense of valuable muscle tissue rather than fat, a priori, that is harmful to health. And if fat gain easy, grow muscles, especially after a certain age - this is a serious job. And the heart, by the way, is also a muscle.
And do not discount the fact that the ketogenic diet propagandists manipulated scientific facts the efficiency of such power for a certain category of patients, such as epilepsy. For people with this or other neurodegenerative diseases, ketogenic diet actually contributes to the underlying disease remission. But as soon as remission is achieved, ketogenic diet is stopped, because it will bring with it, while continuing to use it, other health problems, are no better than those available.
In short, the ketogenic diet - a unreasonable hope for getting rid of excess fat tissueand. You lose weight, but only at the beginning, and only by the muscles, that is worsening rather than improving their health.
Your doctor Pavlova
