About 20 years ago, when people were actively reducing blood cholesterol, there were separate reports that statins cause depression, someone hanged themselves or rushed at people. Then it was not confirmed. Well, that is, there were rare cases of intolerance, and when millions of people began to swallow statins, then rare cases of anything began to be associated with statins. On average, people with headaches got better because they effectively controlled their cholesterol levels and felt protected from strokes with heart attacks.
All these twenty years, there have been reports here and there about how statins affect the mind. Sometimes they worked well, and sometimes not so much. Then it became clear that they were testing this case on already elderly people with a bunch of diseases, in which, even without any medicine, their heads suddenly began to work incorrectly.
Among these weirdos, there were really characters who were sensitive to the side effects of statins, who got worse in the head on statins, and got better when they stopped. Such problems were solved by switching to other statins. Usually from fat soluble to water soluble. Water-soluble statins penetrate less where they shouldn't.
Gradually, those young people who already had high cholesterol in the blood and took statins for this reason matured, matured, wore out and got old. Among them, dementia began to appear. And now it's time to calculate and decide how statins affect the risk of dementia.
They calculated, and it turned out that the relative risk of dementia decreased by about 15-40%. And there was no difference whether they were water-soluble statins or fat-soluble. It turns out that all these old depressions, brain problems and other side effects were just side effects that are rare and unpredictable.
In fact, statins protected against dementia. There were two explanations. First, we decided that statins could somehow directly affect the deposition of those harmful proteins in nerve cells. Secondly, statins protected against atherosclerosis of the cerebral artery. Such people were less likely to develop vascular dementia from minor strokes, and various other types of dementia progressed more slowly. Because if a stroke sits on top of any dementia, then such dementia is immediately aggravated.
Something like this…
