We have here under article on pancreatitis there was a very interesting question about enteric omeprazole.
Omeprazole belongs to the so-called proton pump blockers, which are the best at suppressing stomach acid production. If there is no acid, then all sorts of gastritis and ulcers heal very quickly.
So omeprazole itself is sensitive to acid. Therefore, drug manufacturers scream at every corner that omeprazole must be enteric. That is, tablets or capsules with omeprazole are required to withstand stomach acid, and dissolve only in the intestines.
On the one hand, this is quite logical.
On the other hand, I see no reason to dwell too much on this. This is my subjective opinion, and it seems that to some extent I was right.
Here's the deal. Omeprazole has long been stamped for a penny by all and sundry. This is a very important medicine. And all sorts of Chinese with Indians and Mexicans are especially good at making such cheap preparations.
The story with enteric omeprazole led to exactly what I feared. I swear until tonight I basically didn’t bother with this enteric solubility. And I guessed it.
The point is, enteric drugs don't just have to be resistant to stomach acid. They must be guaranteed to dissolve in the intestines. And just with the intestinal adventures of cheap omeprazole, strange things arose.
It turned out that generic omeprazole from poorer countries, even if it could withstand stomach acid, did not want to dissolve in the intestines according to all the rules. He just didn't act.
And in this matter, time plays a very important role. It is necessary that omeprazole is guaranteed (blood from the nose!) Is absorbed into the blood before breakfast. Because by the time the stomach starts up, omeprazole must watch for proton pumps and block them at the right time. And then suddenly omeprazole is late due to enteric capsules. It turned out offensively.
In addition, omeprazole compares favorably with other drugs in that it will not resignedly wait until the stomach acid destroys it. He blocks this acid himself. And even if on the first day the acid was victorious, then on the second day omeprazole will suppress it and will do whatever he wants.
In short, there are omeprazole in enteric tablets and plain tablets, in enteric capsules and plain capsules. It may very well be that there is no fundamental difference.
Have you bothered about its enteric solubility?
