We are with you yesterday we discussed amlodipine, and immediately a question arose about the fashionable Escordi Cor, in which, allegedly, amlodipine has a different formula.
In fact, his formula is the same, it's just that it's active. isomer amlodipine. Among medicines, this is often the case. Isomers have the same formula, but are wrapped differently in space. Like the right and left arms seem to be the same, but if the right arm is transplanted to the place of the left arm, then it will not be very convenient to use such a transplanted arm.
So in the tablet of the drug there can be two mirror-like variants of the active substance, which differ in their properties. It so happens that one isomer also acts, but not very active, and as ballast loads the kidneys and liver. It would be good to replace it with a more active isomer. Then it would be possible to get by with a smaller dose, and the kidneys and liver would be slightly rested. Well, in principle, there would be fewer side effects.
But it doesn't always work that well. Sometimes the inactive isomer is inactive at all. That is, it does not work and literally lies like ballast.
In the case of EsCordi Cor, the tablet contains not two isomers of amlodipine, but only one levorotatory isomer. It acts like regular amlodipine, only the dose is half as much.
Three points confuse me here:
- Countries like China or India are especially zealous for left-sided amlodipine. They have a powerful pharmaceutical industry and can cook anything. And at the same time, these countries are famous for the fact that they sell drugs, which for some reason are viewed with suspicion in the West.
- I have not heard anything about the properties of dextrorotatory amlodipine. Maybe he does not harm anyone in any way and there is no point in pulling him out of the pill by force, and also giving extra money for it.
- Indian manufacturers of left-sided amlodipine boasted about ten years ago that the legs swell less from it. And this is incomprehensible to me at all. Because the swelling of the legs is associated with the direct action of amlodipine. If the dose is small, then the legs do not swell. If the dose is decent, then the legs swell. I am plagued by vague doubts that this left amlodipine is simply weaker. Therefore, the legs swell less.
And in general, the old amlodipine, consisting of a mixture of right and left, has already established itself as a medicine that saves lives. But the new fashionable left amlodipine has yet to prove its right to save people.
So I wouldn't be particularly happy about the new amlodipine yet.
