People with autoimmune diseases such as rheumatoid arthritis and lupus often get a variety of dangerous infections. This is due to the disease itself or due to treatment with immunosuppressive drugs. They would be vaccinated, but difficulties arise.
Rheumatological patients can easily die from influenza or pneumococcal pneumonia. Advanced rheumatology experts have already lost their voices, explaining that such patients must be vaccinated. But patients for some reason often turn out to be unvaccinated.
Sometimes the attending physicians on the ground are weird, and sometimes the patients themselves are weaned.
In theory, such patients need to be vaccinated before they began to suppress their immunity with special drugs. This is especially important for live vaccines like measles and rubella. In immunocompromised people, these vaccines alone can cause illness. If a person has not yet been taken into circulation by a rheumatologist, that is about 2 to 4 weeks to be vaccinated with a live vaccine.
Pregnant
You and I seem to have discussed once live vaccines that are not prescribed for pregnant women. Because their immunity is not very good. During pregnancy, the immune system is deliberately suppressed by the woman's body, so that it does not in the heat of the moment do something to the child. So even a weakened virus can be dangerous for them.
Killed vaccines
In fact, killed vaccines such as pneumococcal and influenza rheumatologic patients can receive without regard to immunosuppressive drugs.
Rituximab
If you really need to get vaccinated correctly, you will have to follow the rules. Some rheumatologic drugs can specifically interfere with the vaccine. For example, the rheumatoid arthritis drug rituximab itself attacks B-lymphocytes, which produce antibodies. That is, the vaccine will not work. Because it is usually for the sake of antibodies that people are vaccinated. If a person manages to get vaccinated less than 2 weeks before rituximab, then antibodies may not be expected.
Adjuvants
These are additives in vaccines that should deliberately irritate the immune system in order for it to respond better to the vaccine. It is believed that such adjuvants are harmful to rheumatological patients. This influences the choice of vaccine.
Influenza vaccine
Three or four components from the influenza virus are added there, but even such a powerful thing is usually well tolerated, and rheumatological disease suffers.
Methotrexate
They pecked out my brain about him. Powerful and popular. Better, of course, to get vaccinated two weeks before methotrexate. But even with methotrexate, you can also get a lot of benefits from the vaccine.
Briefly speaking
If the vaccine is without an adjuvant, then it will not harm rheumatological patients.
If the vaccine is killed, that even with a bunch of components inside, it is well tolerated by rheumatological patients.
Most rheumatological agents reduce the effect of vaccines, but not fundamentally.
The only exception is rituximab. It just deliberately, by its mean nature, suppresses the production of antibodies.
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