There are a lot of overweight people now. They eat fatty stuff, and this fat is stored as triglycerides in adipose tissue. This is a normal option for storing extra calories. Triglycerides are literally oil. It lies and does not touch anyone.
But overweight people do not always control their appetite and regularly eat fatty foods. Then the excess oil does not fit into the fat cells, it pours over the edge and ends up in the wrong place. We have already discussed blood triglycerides that can cause in humans acute pancreatitis.
If oil drops enter the kidneys, they can ruin them. The harmful effects of fat are called lipotoxicity.
It is generally accepted that it is not the oil itself that harms the kidneys, but all sorts of fatty acids or ceramides. Remember ceramides? These are the kind of fatty things that are constantly advertised in the care products.
And all these undigested fat-like substances in the bad direction readjust the metabolism in the kidneys.
To utilize fatty acids, our cells need a lot of oxygen, but cells suffer from excess oxygen. It's like in history about mildronate.
Recently British (as one might guess) scientists decided to investigate this case in more detail. They gutted a large number of fruit flies, which, by an interesting coincidence, almost like humans, can accumulate fat in the kidneys. It turned out that those very drops of fat in kidney cells not only harm, but can also play a protective role.
Inside such droplets, harmful fat gets stuck, useful fats are released into the contents of the cells, and enzymes on the surface of the droplets digest everything that is superfluous.
Scientists decided that without these very droplets, the harmful fat would have burned out the unfortunate fly buds. The British immediately turned on the fantasy that, like if you spur beneficial enzymes on fat drops and digest excess fat, then it will be possible to save some people already damaged kidneys. What do they not think up!
