Why veroshpiron won't help with chest pain, and how primrose overcame evidence-based medicine

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Not for the first time I have already heard that someone prescribed veroshpiron for recurrent chest pains. This is stupidity.

First, veroshpiron, on the contrary, provokes chest pain in both men and women. Because it changes the action of some hormones.

Secondly, veroshpiron as a diuretic will not remove swelling from the chest. Because this edema is not kept due to the total amount of water in the body, but due to hormones. If diuretics helped in such cases, then none of the suffering women would be ashamed to throw in a powerful loop diuretic like furosemide. But no, they don't help.

So veroshpiron - into the furnace.

Now about evening primrose oil. It is a biologically active food supplement. It contains the so-called gamma-linolenic acid. This acid somehow affects prostaglandins or some other inflammatory substance, and reduces recurrent chest pain.

Evening primrose oil has been tried to be tested in scientific research for reducing the same chest pain. And... nothing happened. It does not work.

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It would seem that from the point of view of evidence-based medicine, this oil is needed - into the furnace. But evidence-based medicine does not dictate one, statistically validated decision. No, evidence-based medicine helps the doctor to accept decision.

Usually experts in some field of medicine study the latest scientific research and decide in the near future to do something according to some rules.

And now an amazing story happened with the primrose. Its effect has not been proven in scientific research. But a certain number of doctors beat themselves in the chest (sorry for the pun!) And swear that primrose helps patients.

The experts figured it out and decided that there is no harm from primrose, maybe it helps someone, the alternative treatment is very rough (there are really anti-cancer drugs), so it can be recommended.

That is, an amazing situation occurred when, in the official algorithm for the management of women with chest pain, they suggested trying evening primrose oil. Personally, I don't remember any similar examples.

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