Nise's real name is nimesulide. For the first time, he announced himself somewhere in 1985. It was a young and promising non-steroidal anti-inflammatory drug with a bright future.
From the very beginning, nimesulide was distinguished by its selectivity. That is, it had an anti-inflammatory effect, lowered body temperature and was good pain relief, but at the same time it irritated the stomach less and did not provoke bleeding too much.
At all times these qualities have been highly appreciated by consumers who have chronic diseases. So there was less chance of running into dangerous side effects with constant use.
Among other things, nimesulide was cheap. They rushed to stamp it in countries like India, where there are pharmaceutical factories, and the people live in poverty.
You probably already guessed that so many beneficial qualities will not be good, and there is a catch somewhere.
And so it happened. It turned out that nimesulide damages the liver of children. If the child's liver is not all right, then it is better to forget about nimesulide.
Then they found out that it is better not to take nimesulide for adults for more than 15 days. This was especially offensive, because selective anti-inflammatory drugs are exactly what you need for long-term use.
Then they began to publish stories of patients whose liver was unfastened within a week.
All these facts came up rarely, but completely unpredictable.
In addition, nimesulide did more than just interfere with the liver's function. He still broke something very badly there. Even after stopping the drug, it did not get better. So until now, they did not understand what exactly nimesulide destroys inside the liver. But if the process has seriously spun, then about every fifth victim had a chance to die.
I will say again that this was rare. There are only a few hundred known cases around the world. But the Americans, for example, were smart enough to refuse nimesulide.
But the Indians were happy. The drug is powerful and cheap.
One Indian scientist published in 2013 a panicky article about the fact that they in India feed children as many as 12 different names of nimesulide.
Here, it seems, the principle of large numbers worked. Side effects are rare, but India has over a billion people. There are many factories that churn out nimesulide, and good medicine that notices all kinds of shoals. Rare but noticeable liver damage began to glow across the country.
There was a fuss about the need to ban this poison altogether. But somehow, in my opinion, these fighters for the truth have their tails pressed. You can't really fight pharmaceutical manufacturers.
Have you already overstocked with nimesulide?
