Let's talk about the connection between dementia, testosterone deficiency and overweight in men. This is one of the least covered, but no less pressing problems.
Even on their own, without communication with each other, these conditions are risk factors for neurodegenerative diseases. - slowly occurring ailments with the death of nerve cells, which lead to dementia (dementia), Alzheimer's and etc.
In 2014 there were a study on mice.
We set the task to find out how an obesity-inducing (i.e. high-calorie) diet and testosterone deficiency affect neural metabolism, indicators of inflammation, both in the central and peripheral parts. Both the general influence and the influence of each factor were investigated separately.
Within 4 months
male mice were fed a diet with a normal level of calorie intake or with excess fat (and calories) food. Then they were sacrificed and the corresponding studies were carried out: RNA was isolated from the cells of the brain and sciatic nerve and the damage to the peripheral nerves was assessed. By a variety of methods, including the level of expression of the myelin sheath protein and the levels of activity of Na +, K + -ATPase (I am writing for specialists).The results were as follows:
1. A high fat diet that promotes obesity and low testosterone levels, both independently and in combination, contribute to the development of neuroinflammation in the central and peripheral nervous system. Hello hot fans of the keto diet and those who are used to eating fatty and satisfying food.
2. Testosterone deficiency and obesity associated with inflammation of adipose tissue increase the risk of developing not only metabolic syndrome, type 2 diabetes mellitus and its complications (including polyneuropathy, atrophy of the upper and lower extremities), but also Alzheimer's disease.
3. Glia cells (a collection of accessory nerve cells) obtained from obese mice retained increased expression of cytokines outside the body. How to translate this phrase into an understandable language? Cytokines are inflammatory factors. This means that obesity inCauses the development of inflammation and leads to a decrease in the immune status. That is, the body is weakened and open to infections.
You can rightly point out that humans are not mice. But the similarity between humans and mice reaches 70%. Many revolutionary discoveries were first made in mice, then confirmed in humans. So there is something to think about.
Your Doctor Pavlova
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