Let's first see what kind of a virus - Coxsackie? It turns out that it is highly contagious and is related to enterovirus infection with the notorious "polymorphic" the clinical picture. And the age of him would not know anything, but in the early stages of the study, conducted by a group of competent professionals, suddenly found that the strain of the virus effectively destroys cancer cells Bladder. And if in the future it is confirmed, it Coxsackie can be used in a special complex immunotherapy.
In this connection it is necessary to know that the oncolytic virus - is a class of virus that finds cancer cells in the human body and kills it either directly destroyed or actively helping to cope with cancer of the immune system (such virus "illuminates" the tumor cells to it).
As for non-muscle invasive bladder cancer (NMIBC), it is one of the most common types of cancers, and difficult to treat. Methods of modern therapy, including various methods of surgery, and chemotherapy or immunotherapy, are unable to eliminate the high frequency of relapses of the disease.
New work in the field of interaction between cancer and viruses describes the first phase of research involving Coxsackie virus strain (CVA21) «as" oncolytic agent aimed at bladder cancer bubble. The study involved 15 patients with NMIBC, CVA21 administered directly into the bladder (via a catheter). A week after the treatment, the patients underwent surgery (they removed the tumors), and it is possible to assess how the virus got into the cancer cells.
The results were promising: tests showed that the virus has penetrated the tumor cells of the bladder in all study participants. Moreover, he did cause the death of cancer cells, and it was noted increase in the number of inflammatory cytokines. This is evidence that the virus stimulates the immune system of the human body, in order to jointly act on the tumor cells, to attack them.
Important:in the course of the experiment There were no significant side effects in any patient.
It should be noted that this is not the first study that uses a common cold virus as an oncolytic agent. In particular, CVA21 gave promising results and is now seriously being considered for inclusion in the therapy of melanoma and prostate cancer. Now there are several human trials evaluating its efficacy in combination with other forms of immunotherapy.
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