By premature sexual development to understand the appearance of symptoms of puberty before the age of 8 years in girls and 9 years old - boys. This pathology may be caused by disturbance in gonadostata system at different levels. Most of the authors adhere to pathogenetic classification outage.
Allocate true or cerebral, form of the disease, the pathogenesis of which is associated with premature impulse hypothalamus secretion. Increased synthesis of sex steroids in these cases due to excessive production of pituitary gonadotropins. Excessive secretion of sex steroids increases the growth rate and contributes to the rapid closing of growth zones.
False forms of the disease can spontaneously transform into true that associated with secondary activation of the hypothalamic-pituitary axis. A special group are the so-called gonadotropinnezavisimye forms in which the autonomous activation of the reproductive glands caused by genetic disorders. These embodiments have all the features deployed puberty - increase gonads, acceleration of bone growth and maturation, the formation of secondary sexual characteristics.
There are patients with the only sign of premature puberty: isolated development Secondary body hair (premature pubarhe) and isolated breast development (premature thelarche). This incomplete form.
The cause of the disease can be a variety of central nervous system (CNS) nonneoplastic nature (Organic, inflammatory et al.), And the impact of adverse factors in utero (trauma hypoxia, infection). These children often show hydrocephalic syndrome. The reason may be arachnoid cyst bottom of the third ventricle and chiasmosellar areas of the brain. Cysts are formed during embryogenesis, at least - as a result of suffering a meningitis, encephalitis, brain injury.
Some patients are unable to identify the cause of the disease. In such cases, the exclusion of organic diseases of CNS is diagnosed idiopathic forms. However, improved techniques (use of computer and MRI) of the brain can detect the cause of most forms of cerebral PPR.
